Let’s work together.
Academic partners, BSc and MSc students, PhD candidates and postdocs: tell us about your project or your background.
- A.
- DBMR, University of Bern
Murtenstrasse 35, CH-3008 Bern
Selected
5 publications- 2023
The predicted RNA-binding protein regulome of axonal mRNAs
R Luisier, C Andreassi, LM Fournier, A Riccio
By integrating 3′ end sequencing from cell body and axonal mRNAs obtained from rat sympathetic neurons with human CLIP sequencing data, we provide fundamental advances to the current knowledge of post-transcriptional mechanisms that regulate neurotrophin-mediated mRNA metabolism in neurons. In collaboration with the Riccio Lab (University College London, Prof. Antonella Riccio).
Genome Research
- 2022
Image-based deep learning reveals the responses of human motor neurons to stress and VCP-related ALS
C Verzat, J Harley, R Patani, R Luisier
By deploying transfer learning with a pre-trained deep-learning image classifier to a rich multichannel fluorescence microscopy high content imaging data-set, we revealed novel neurite-associated morphological perturbations in ALS disease. In collaboration with the Patani Lab (Francis Crick Institute, London, Prof. Rickie Patani).
Neuropathology and Applied Neurobiology
- 2022
Automated and unbiased discrimination of ALS from control tissue at single cell resolution
C Hagemann, GE Tyzack, DM Taha, H Devine, L Greensmith, J Newcombe, R Patani, A Serio, R Luisier
By combining automated image processing with machine learning methods, we developed a method that enables automatic identification of sick cells with unprecedented accuracy and at single cell resolution in histopathological tissue sections. In collaboration with the Patani Lab (Francis Crick Institute, London) and the Serio Lab (King’s College, London, Dr Andrea Serio).
Brain Pathology
- 2022
Physiological intron retaining transcripts in the cytoplasm abound during human motor neurogenesis
MP Howe, H Crerar, J Neeves, J Harley, GE Tyzack, P Klein, A Ramos, R Patani, R Luisier
Together with the study below, this work shows that aberrant cytoplasmic intron retaining transcripts represent a widespread phenomenon in ALS, and that these intronic sequences exhibit specific features enabling them to create a mislocalization-prone environment for proteins.
Genome Research
- 2021
Aberrant cytoplasmic intron retention is a blueprint for RNA binding protein mislocalization in VCP-related amyotrophic lateral sclerosis
GE Tyzack, J Neeves, H Crerar, P Klein, O Ziff, DM Taha, R Luisier, NM Luscombe, R Patani
Points towards a role of intronic sequences as regulators of protein localisation, and a potential role for cytoplasmic intronic sequences in regulating miRNA functionality.
Brain
Provisional List and summaries from luisierlab.com/publications (2021–2023); links open a Google Scholar search. To be updated by the lab.
Contact