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- A.
- DBMR, University of Bern
Murtenstrasse 35, CH-3008 Bern
AI and data science lab for RNA biology, in Bern.
Raphaëlle Luisier Principal Investigator DBMR · Bern Contact → The lab
We combine sequencing, imaging, proteomics, histopathology and clinical data with machine learning, to understand what the non-coding regions of mRNA do in neurodegeneration and cancer.
We combine sequencing, imaging and clinical data with machine learning, to understand what non-coding regions of mRNA do in disease.
Based at the Department for BioMedical Research of the University of Bern, the lab is affiliated with the SIB Swiss Institute of Bioinformatics and the NCCR RNA & Disease.
Vision
More than 80% of the human transcriptome is non-coding mRNA sequence. Understanding what it does could open the way to new RNA-based therapies.
Source: luisierlab.com/research
Research
All research →All →-
Provisional image Hidden functions of non-coding mRNA
RNA biologyHow 5′ UTRs, introns and 3′ UTRs are expressed, and what they do, in different cell types.
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Provisional image Omics meets imaging
BioinformaticsMethods to quantify non-coding mRNA regions in bulk, single-cell and spatial transcriptomics.
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Provisional image From genotype to phenotype
Bioimage analysisSegmentation-free pipelines for histopathology, fluorescence and cell images.
- Provisional image
From neurodegeneration to cancer
DiseaseFrom motor neurons and astrocytes to cancer therapy resistance, towards RNA-based therapies.
Key Elements
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Non-Coding mRNA
We investigate the often-overlooked 5′ UTR, introns, and 3′ UTR of mRNA, pushing boundaries beyond their traditional functions.
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Bioinformatics Expertise
We develop advanced computational tools to quantify non-coding mRNA in large-scale datasets, merging omics and imaging data for insights.
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Phenotype Insights
We strive to link aberrant non-coding RNA to cellular and tissue-level abnormalities, from neurodegeneration to cancer.
Latest publications
All publications →All →- 2023
Genome Research
- 2022
Image-based deep learning reveals the responses of human motor neurons to stress and VCP-related ALS
Neuropathology and Applied Neurobiology
- 2022
Brain Pathology
Team
Meet our team →All →- Raphaëlle Luisier Principal Investigator
- Zhi Ming Xu Postdoctoral researcher
- Elisa Messori PhD candidate
- Lisa Fournier PhD candidate
- Filipa Torrão MSc student
- Keigo Shibata Visiting researcher
- Roman Shaposhnikov Visiting researcher
Contact